Methyl 4-amino-3-fluorobenzoate → 4-{2-[2-(4-Chloro-phenyl)-2,4,5,6-tetrahydro-cyclopentapyrazol-3-yl]-2-cyclohexyl-acetylamino}-3-fluoro-benzoic acid methyl ester

HRID 889379ノート

反応式

HRID 889379 の反応式
FC1C([O:8][C:9](=O)[CH:10]([C:17]2[N:18]([C:25]3[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][CH:26]=3)[N:19]=[C:20]3[CH2:24][CH2:23][CH2:22][C:21]=23)[CH:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)=C(F)C(F)=C(F)C=1F.[CH3:37][O:38][C:39](=[O:48])[C:40]1[CH:45]=[CH:44][C:43]([NH2:46])=[C:42]([F:47])[CH:41]=1>CN(C1C=CN=CC=1)C.CN(C=O)C>[CH3:37][O:38][C:39](=[O:48])[C:40]1[CH:45]=[CH:44][C:43]([NH:46][C:9](=[O:8])[CH:10]([C:17]2[N:18]([C:25]3[CH:26]=[CH:27][C:28]([Cl:31])=[CH:29][CH:30]=3)[N:19]=[C:20]3[CH2:24][CH2:23][CH2:22][C:21]=23)[CH:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)=[C:42]([F:47])[CH:41]=1

参加物

5

反応物 2

HCID 11182865Methyl 4-amino-3-fluorobenzoateHCID 86657983[2-(4-Chloro-phenyl)-2,4,5,6-tetrahydro-cyclopentapyrazol-3-yl]-cyclohexyl-acetic acid pentafluorophenyl ester

生成物 1

HCID 673878384-{2-[2-(4-Chloro-phenyl)-2,4,5,6-tetrahydro-cyclopentapyrazol-3-yl]-2-cyclohexyl-acetylamino}-3-fluoro-benzoic acid methyl ester

試薬・触媒・溶媒 2

HCID 142844-(Dimethylamino)pyridine触媒HCID 6228Dimethylformamide溶媒

実験手順

In analogy to the procedure described in example 4.3, [2-(4-chloro-phenyl)-2,4,5,6-tetrahydro-cyclopentapyrazol-3-yl]-cyclohexyl-acetic acid pentafluorophenyl ester (example 4.2) was reacted with 4-amino-3-fluoro-benzoic acid methyl ester (CAS Reg. No. 185629-32-7) in the presence of DMAP in DMF to give the title compound as colorless oil. MS: m/e=510.2 [M+H+].

出典と根拠

ORDレコード
ord-b8637f3c1a0940558ca419c0740ea039
出典データセット
uspto-grants-2012_08
特許番号
US08252826B2

反応ノート

読み込み中…