4-Chloro-2-methyl-5-nitroaniline → N-(4-chloro-2-methyl-5-nitrophenyl)methanesulfonamide

HRID 889446

反応式

HRID 889446 の反応式
[Cl:1][C:2]1[C:8]([N+:9]([O-:11])=[O:10])=[CH:7][C:5]([NH2:6])=[C:4]([CH3:12])[CH:3]=1.C(C1C=CC([N+]([O-])=O)=CC=1N[S:25]([CH3:28])(=[O:27])=[O:26])C>>[Cl:1][C:2]1[C:8]([N+:9]([O-:11])=[O:10])=[CH:7][C:5]([NH:6][S:25]([CH3:28])(=[O:27])=[O:26])=[C:4]([CH3:12])[CH:3]=1

参加物

3

反応物 2

HCID 2929654-Chloro-2-methyl-5-nitroanilineHCID 59313849N-(2-ethyl-5-nitrophenyl)methanesulfonamide

生成物 1

HCID 67359857N-(4-chloro-2-methyl-5-nitrophenyl)methanesulfonamide

実験手順

Intermediate 79A was prepared from 4-chloro-2-methyl-5-nitroaniline following the procedure employed in the preparation of Intermediate 78A. HPLC: Rt=1.618 min. (CHROMOLITH® column 4.6×50 mm eluting with 10-90% aqueous methanol over 4 min. containing 0.1% TFA, 4 mL/min., monitoring at 220 nm). MS (ES): m/z=265 [M+H]+.

後処理

  1. washHPLC: Rt=1.618 min. (CHROMOLITH® column 4.6×50 mm eluting with 10-90% aqueous methanol over 4 min. containing 0.1% TFA, 4 mL/min., monitoring at 220 nm)

出典と根拠

ORDレコード
ord-ff5e1cd0c2a5486fa1bb29d77912bb22
出典データセット
uspto-grants-2012_08
特許番号
US08252795B2

関連ノート

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