化工社化工社 化学情報印刷レポート · 研究参考用
Water → 1-{6-[1-(2-Chloro-4,6-dimethylphenylimino)ethyl]pyridin-2-yl}ethanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | p-Toluenesulfonic acid | HCID 6101 | — |
| 反応物 | 2,6-Diacetylpyridine | HCID 70790 | — |
| 反応物 | 2-Chloro-4,6-dimethylaniline | HCID 113033 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 1-{6-[1-(2-Chloro-4,6-dimethylphenylimino)ethyl]pyridin-2-yl}ethanone | HCID 59464624 | 5.1% |
反応手順
10 g of 2,6-diacetylpyridine (0.0613 mol), 9.54 g of 2-chloro-4,6-dimethylaniline (0.0613 mol) and 0.6 g of p-toluenesulfonic acid were heated under reflux on a water separator in 400 ml of methanol for 90 min. The solvent was distilled off completely and the residue was recrystallized twice from 50 ml of isopropanol. 0.92 g (0.0031 mol) of 1-{6-[1-(2-chloro-4,6-dimethyl-phenylimino)ethyl]pyridin-2-yl}ethanone was obtained in a yield of 5%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08252875B2 |
| 出典データセット | uspto-grants-2012_08 |
| ORD ID | ord-2a00147b60d54063851410655042b711 |
| 出典メモ | uspto-grants-2012_08 |