N1,5'-O-dibenzyl-2',3'-didehydro-2',3'-dideoxyinosine → N1,5'-O-dibenzyl-2',3'-dideoxyinosine

HRID 889574ノート

反応式

HRID 889574 の反応式
[CH2:1]([N:8]1[CH:30]=[N:29][C:28]2[N:13]([C@@H:14]3[O:27][C@H:17]([CH2:18][O:19][CH2:20][C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)[CH:16]=[CH:15]3)[CH:12]=[N:11][C:10]=2[C:9]1=[O:31])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H][H]>[C].[Pd].CO>[CH2:1]([N:8]1[CH:30]=[N:29][C:28]2[N:13]([C@@H:14]3[O:27][C@H:17]([CH2:18][O:19][CH2:20][C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)[CH2:16][CH2:15]3)[CH:12]=[N:11][C:10]=2[C:9]1=[O:31])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 2

HCID 11683075N1,5'-O-dibenzyl-2',3'-didehydro-2',3'-dideoxyinosineHCID 178418361HCID 178418361、化合物

生成物 1

HCID 11647353N1,5'-O-dibenzyl-2',3'-dideoxyinosine収率 90%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 887Methanol溶媒

実験手順

To a methanol solution (1 mL) of N1,5′-O-dibenzyl-2′,3′-didehydro-2′,3′-dideoxyinosine (207 mg, 0.5 mmol), 5% palladium-carbon (20 mg) was added, and the mixture was stirred at room temperature for 2 hours in an atmosphere of hydrogen (1 atm). The palladium catalyst was removed from the obtained reaction mixture by filtration, and the resultant filtrate was concentrated under reduced pressure. After purification by chromatography (using 15 g of silica gel and ethyl acetate as an eluting solution), 187 mg of the intended product was obtained in a yield of 90% as a white solid.

後処理

  1. customThe palladium catalyst was removed from the obtained reaction mixture by filtration
  2. concentrationthe resultant filtrate was concentrated under reduced pressure
  3. customAfter purification by chromatography (
  4. customwas obtained in a yield of 90% as a white solid

出典と根拠

ORDレコード
ord-0b6a2586d998423c9507f8712130dcc1
出典データセット
uspto-grants-2012_08
特許番号
US08252920B2

反応ノート

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