Potassium Cyanide → Methyl 5-cyanopentanoate
反応式
[C-:1]#[N:2].[K+].Br[CH2:5][CH2:6][CH2:7][CH2:8][C:9]([O:11][CH3:12])=[O:10]>O.CO>[C:1]([CH2:5][CH2:6][CH2:7][CH2:8][C:9]([O:11][CH3:12])=[O:10])#[N:2]参加物
5
実験手順
Potassium Cyanide (4 g, 61.44 mmol) is dissolved in 70 mL water and 200 mL methanol. To the solution 10 g (51.2 mmol) of methyl 5-bromopentanoate is added and the mixture is refluxed overnight. The reaction mixture is concentrated to dryness. To the residue, 100 mL of EtOAc is added to extract the product. The organic is washed with water three times, dried and concentrated to yield 5.37 g (74%) of methyl 5-cyanopentanoate as an oil.
後処理
- temperaturethe mixture is refluxed overnight
- concentrationThe reaction mixture is concentrated to dryness
- additionTo the residue, 100 mL of EtOAc is added
- extractionto extract the product
- washThe organic is washed with water three times
- customdried
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-1b8890dafda348389a075e1b117b04a4
- 出典データセット
- uspto-grants-2012_08
- 特許番号
- US08252923B2
反応ノート
読み込み中…