Potassium Cyanide → Methyl 5-cyanopentanoate

HRID 889579

反応式

HRID 889579 の反応式
[C-:1]#[N:2].[K+].Br[CH2:5][CH2:6][CH2:7][CH2:8][C:9]([O:11][CH3:12])=[O:10]>O.CO>[C:1]([CH2:5][CH2:6][CH2:7][CH2:8][C:9]([O:11][CH3:12])=[O:10])#[N:2]

参加物

5

反応物 2

HCID 9032Potassium CyanideHCID 79557Methyl 5-bromovalerate

生成物 1

HCID 554130Methyl 5-cyanopentanoate収率 74.3%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

Potassium Cyanide (4 g, 61.44 mmol) is dissolved in 70 mL water and 200 mL methanol. To the solution 10 g (51.2 mmol) of methyl 5-bromopentanoate is added and the mixture is refluxed overnight. The reaction mixture is concentrated to dryness. To the residue, 100 mL of EtOAc is added to extract the product. The organic is washed with water three times, dried and concentrated to yield 5.37 g (74%) of methyl 5-cyanopentanoate as an oil.

後処理

  1. temperaturethe mixture is refluxed overnight
  2. concentrationThe reaction mixture is concentrated to dryness
  3. additionTo the residue, 100 mL of EtOAc is added
  4. extractionto extract the product
  5. washThe organic is washed with water three times
  6. customdried
  7. concentrationconcentrated

出典と根拠

ORDレコード
ord-1b8890dafda348389a075e1b117b04a4
出典データセット
uspto-grants-2012_08
特許番号
US08252923B2

関連ノート

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