1,2-Dichloroethane → HCID 22249396、化合物

反応式

[CH3:1][C:2]1([CH3:14])[C:10]2[C:5](=[CH:6][C:7]([N+:11]([O-:13])=[O:12])=[CH:8][CH:9]=2)[NH:4][CH2:3]1.C1[CH:20]=[N:19][C:18]2N(O)N=NC=2C=1.[CH2:25](Cl)[CH2:26]Cl.CN(C=[O:33])C>C(Cl)Cl>[CH3:18][N:19]([CH3:20])[CH2:25][C:26]([N:4]1[C:5]2[C:10](=[CH:9][CH:8]=[C:7]([N+:11]([O-:13])=[O:12])[CH:6]=2)[C:2]([CH3:14])([CH3:1])[CH2:3]1)=[O:33]

参加物

実験手順

3,3-Dimethyl-6-nitro-2,3-dihydro-1H-indole (5 g) was dissolved in DMF (100 ml) and HOAt (3.89 g) dimethylamino-acetic acid (5.83 g) and EDC (3.89 g) were added. The reaction was stirred overnight. The mixture was diluted with CH2Cl2 (1 L) and washed with sat'd NaHCO3 (3×200 ml). The organic layer was washed with brine, dried over Na2SO4, filtered and concentrated in vacuo. The residue was purified by flash chromatography (SiO2, EtOAc to 5%MeOH/EtOAc) to afford the title compound.