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Hydrochloric Acid → 3-(3-Phenyl-2-propene-1-yl) 5-(2-cyanoethyl) 4-(3-chlorophenyl)-2-formyl-6-methyl-1,4-dihydropyridine 3,5-dicarboxylate

HRID 890150
ノート
印刷プレビュー

反応式

HRID 890150 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]2[C:13]([C:14]([O:16][CH2:17][CH2:18][C:19]#[N:20])=[O:15])=[C:12]([CH3:21])[NH:11][C:10]([CH:22](OC)[O:23]C)=[C:9]2[C:27]([O:29][CH2:30][CH:31]=[CH:32][C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)=[O:28])[CH:5]=[CH:6][CH:7]=1.Cl>CC(C)=O>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]2[C:13]([C:14]([O:16][CH2:17][CH2:18][C:19]#[N:20])=[O:15])=[C:12]([CH3:21])[NH:11][C:10]([CH:22]=[O:23])=[C:9]2[C:27]([O:29][CH2:30][CH:31]=[CH:32][C:33]2[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=2)=[O:28])[CH:5]=[CH:6][CH:7]=1
参加物反応条件実験手順後処理出典と根拠反応ノート

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 695899473-(3-Phenyl-2-propene-1-yl) 5-(2-cyanoethyl) 4-(3-chlorophenyl)-2-dimethoxylmethyl-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

生成物 1

HCID 743481133-(3-Phenyl-2-propene-1-yl) 5-(2-cyanoethyl) 4-(3-chlorophenyl)-2-formyl-6-methyl-1,4-dihydropyridine 3,5-dicarboxylate

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

反応条件

温度
0 °C

実験手順

1.82 g (3.38 mmol) of 3-(3-phenyl-2-propene-1-yl) 5-(2-cyanoethyl) 4-(3-chlorophenyl)-2-dimethoxylmethyl-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate was dissolved in 12.7 ml of acetone. 1.27 ml of 6 N hydrochloric acid was added to the obtained solution, and they were stirred at 0° C. for 6 hours. Acetone was evaporated under reduced pressure, and then water was added to the residue. After the extraction with chloroform, the organic layer was successively washed with a saturated aqueous sodium hydrogencarbonate solution and saturated aqueous salt solution, and then dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure and the residue was purified by the silica gel chromatography (hexane/ethyl acetate=3/1) to obtain the title compound.

後処理

  1. customAcetone was evaporated under reduced pressure
  2. additionwater was added to the residue
  3. extractionAfter the extraction with chloroform
  4. washthe organic layer was successively washed with a saturated aqueous sodium hydrogencarbonate solution and saturated aqueous salt solution
  5. dry with materialdried over anhydrous sodium sulfate
  6. customThe solvent was evaporated under reduced pressure
  7. customthe residue was purified by the silica gel chromatography (hexane/ethyl acetate=3/1)

出典と根拠

ORDレコード
ord-25fb0ce6d8a24b0abadc7aac46fd4a79
出典データセット
uspto-grants-2006_02
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US06995179B2

反応ノート

読み込み中…

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