Water → 5-(2-Phenylcyclopropylmethyl) 3-(2-cyanoethyl) 4-(3-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine 3,5-dicarboxylate

関与物質

役割	名称	HCID	仕込み量
反応物	Water	HCID 962	—
反応物	(2-Phenylcyclopropyl)methanol	HCID 317540	—
反応物	1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride	HCID 2723939	—
反応物	Mono(2-cyanoethyl) 4-(3-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate	HCID 86757801	—
触媒	4-(Dimethylamino)pyridine	HCID 14284	—
溶媒	Dichloromethane	HCID 6344	—
生成物	5-(2-Phenylcyclopropylmethyl) 3-(2-cyanoethyl) 4-(3-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine 3,5-dicarboxylate	HCID 69589908	—

反応手順

306 mg (0.85 mmol) of mono(2-cyanoethyl) 4-(3-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, 188 mg (1.27 mmol) of 2-phenylcyclopropylmethanol, 243 mg (1.27 mmol) of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and 23 mg (0.18 mmol) of 4-dimethylaminopyridine were stirred together in 10 ml of dichloromethane at room temperature for one hour. Water was added to the reaction liquid. After the extraction with dichloromethane, the organic layer was dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by the silica gel chromatography (hexane/ethyl acetate=2/1) to obtain the title compound.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US06995179B2
出典データセット	uspto-grants-2006_02
ORD ID	ord-cda1fc1327294a808d5589be2ccb1ce6
出典メモ	uspto-grants-2006_02