2-Acetylbutyrolactone → 3-[1-(3-Iodoanilino)ethylidene]tetrahydro-2-furanone

HRID 890202

反応式

HRID 890202 の反応式
[I:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][CH:8]=1)[NH2:5].[C:9]([CH:12]1[CH2:17][CH2:16][O:15][C:13]1=[O:14])(=O)[CH3:10]>C(O)C>[I:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][CH:8]=1)[NH:5][C:9](=[C:12]1[CH2:17][CH2:16][O:15][C:13]1=[O:14])[CH3:10]

参加物

4

反応物 2

HCID 106012-AcetylbutyrolactoneHCID 122713-Iodoaniline

生成物 1

HCID 695835373-[1-(3-Iodoanilino)ethylidene]tetrahydro-2-furanone収率 99.6%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 3-iodoaniline (5.0 g, 23 mmol), α-acetyl-γ-butyrolactone (14.6 g, 0.11 mol) in ethanol (100 mL) was heated under reflux for seven days. The mixture was evaporated, and the residue was purified by silica gel column chromatography (10% ethyl acetate/hexane), to give the title compound (7.54 g) as white crystals.

後処理

  1. temperatureunder reflux for seven days
  2. customThe mixture was evaporated
  3. customthe residue was purified by silica gel column chromatography (10% ethyl acetate/hexane)

出典と根拠

ORDレコード
ord-1dc069704bc74b65afd80a761e85316b
出典データセット
uspto-grants-2006_02
特許番号
US06995163B2

関連ノート

読み込み中…