1-Indanone → Indeno(1,2-b)indole

HRID 890324

反応式

HRID 890324 の反応式
[C:1]1(=O)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.Cl.[C:12]1(C)[CH:17]=[CH:16][C:15]([NH:18]N)=[CH:14][CH:13]=1>CCO.Cl>[CH:5]1[CH:6]=[CH:7][CH:8]=[C:9]2[C:4]=1[CH:3]=[C:2]1[C:16]3[CH:17]=[CH:12][CH:13]=[CH:14][C:15]=3[N:18]=[C:1]12

参加物

5

反応物 2

HCID 67351-IndanoneHCID 125044-Methylphenylhydrazine monohydrochloride

生成物 1

HCID 12963293Indeno(1,2-b)indole

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 702Ethanol溶媒

実験手順

A mixture of 1-indanone (30.6 g, 232 mmol) and p-tolylhydrazine hydrochloride (37.0 g, 233 mmol) in EtOH (350 mL) and aqueous HCl (12 N, 18 mL) are heated to reflux for 90 min. The mixture is cooled and filtered, and the solid is washed with EtOH (600 mL) followed by 20% aqueous EtOH (400 mL) and finally hexanes (200 mL). The off-white solid is dried under vacuum (36.5 g, 72%).

後処理

  1. temperatureare heated
  2. temperatureto reflux for 90 min
  3. temperatureThe mixture is cooled
  4. filtrationfiltered
  5. washthe solid is washed with EtOH (600 mL)
  6. customThe off-white solid is dried under vacuum (36.5 g, 72%)

出典と根拠

ORDレコード
ord-3cb42a85ce85420d96f45874283b8385
出典データセット
uspto-grants-2006_02
特許番号
US06995216B2

関連ノート

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