Cesium carbonate → {5-[4-Cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-ylmethoxy]-indol-1-yl}-acetic acid ethyl ester

HRID 890429

反応式

HRID 890429 の反応式
Cl[CH2:2][C:3]1[C:4]([CH:19]2[CH2:21][CH2:20]2)=[N:5][C:6]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)=[N:7][CH:8]=1.[CH2:22]([O:24][C:25](=[O:37])[CH2:26][N:27]1[C:35]2[C:30](=[CH:31][C:32]([OH:36])=[CH:33][CH:34]=2)[CH:29]=[CH:28]1)[CH3:23].C(=O)([O-])[O-].[Cs+].[Cs+]>>[CH2:22]([O:24][C:25](=[O:37])[CH2:26][N:27]1[C:35]2[C:30](=[CH:31][C:32]([O:36][CH2:2][C:3]3[C:4]([CH:19]4[CH2:21][CH2:20]4)=[N:5][C:6]([C:9]4[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=4)=[N:7][CH:8]=3)=[CH:33][CH:34]=2)[CH:29]=[CH:28]1)[CH3:23]

参加物

4

反応物 3

HCID 10796Cesium carbonateHCID 219359605-Chloromethyl-4-cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidineHCID 57675474(5-Hydroxy-indol-1-yl)-acetic acid ethyl ester

生成物 1

HCID 69642003{5-[4-Cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-ylmethoxy]-indol-1-yl}-acetic acid ethyl ester

実験手順

In analogy to the procedure described in example 1 h], 5-chloromethyl-4-cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidine was reacted with (5-hydroxy-indol-1-yl)-acetic acid ethyl ester (example 1 c]) in the presence of cesium carbonate to give {5-[4-cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-ylmethoxy]-indol-1-yl}-acetic acid ethyl ester, which was subsequently treated with lithium hydroxide in analogy to the procedure described in example 1 i] to yield {5-[4-cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-ylmethoxy]-indol-1-yl}-acetic acid.

後処理

  1. customdescribed in example 1 h

出典と根拠

ORDレコード
ord-4a5f7624697045fba29eb493d67a60c5
出典データセット
uspto-grants-2006_02
特許番号
US06995263B2

関連ノート

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