3-Amino-3-cyclopropyl-acrylic acid ethyl ester → 2-Cyclopropyl-6-(4-trifluoromethoxy-phenyl)-4-trifluoromethyl-nicotinic acid ethyl ester
反応式
[CH2:1]([O:3][C:4](=[O:11])[CH:5]=[C:6]([NH2:10])[CH:7]1[CH2:9][CH2:8]1)[CH3:2].[F:12][C:13]([F:31])([F:30])/[C:14](/O)=[CH:15]/[C:16]([C:18]1[CH:23]=[CH:22][C:21]([O:24][C:25]([F:28])([F:27])[F:26])=[CH:20][CH:19]=1)=O>>[CH2:1]([O:3][C:4](=[O:11])[C:5]1[C:14]([C:13]([F:12])([F:31])[F:30])=[CH:15][C:16]([C:18]2[CH:23]=[CH:22][C:21]([O:24][C:25]([F:26])([F:27])[F:28])=[CH:20][CH:19]=2)=[N:10][C:6]=1[CH:7]1[CH2:8][CH2:9]1)[CH3:2]参加物
3
実験手順
In analogy to the procedure described in example 18 d], 3-amino-3-cyclopropyl-acrylic acid ethyl ester (J. P. Célérier, E. Deloisy, P. Kapron, G. Lhommet, P. Maitte, Synthesis 1981, 130–133) was reacted with (Z)-4,4,4-trifluoro-3-hydroxy-1-(4-trifluoromethoxy-phenyl)-but-2-en-1-one (example 16 a]) to give the title compound as colorless oil.
後処理
- customdescribed in example 18 d