化工社化工社 化学情報印刷レポート · 研究参考用
4-Amino-3-methylbenzenesulfonic acid → 4-Amino-3-methylbenzene-1-sulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Amino-3-methylbenzenesulfonic acid | HCID 7384 | — |
| 反応物 | Ammonium Hydroxide | HCID 14923 | — |
| 反応物 | Oxalyl chloride | HCID 65578 | — |
| 反応物 | Chloro-N,N-dimethylformiminium chloride | HCID 77311 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 4-Amino-3-methylbenzene-1-sulfonamide | HCID 143037 | — |
反応手順
For example, commercially available 2-aminotoluene-5-sulfonic acid was allowed to react with Villsmeyer reagent (N-(chloromethylene)-N-methylmethanaminium chloride), that is either commercially prepared or is generated in situ from a mixture of N,N-dimethylformamide and oxalyl chloride. The intermediate compound was then allowed to react with ammonium hydroxide in tetrahydrofuran to afford 4-amino-3-methylbenzenesulfonamide (Scheme IV).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06995283B2 |
| 出典データセット | uspto-grants-2006_02 |
| ORD ID | ord-a0a0ea1488d74ce487d09f56374d3ea1 |
| 出典メモ | uspto-grants-2006_02 |