関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Sodium Sulfate | HCID 24436 | — |
| 反応物 | (+)-Pantolactone | HCID 736053 | — |
| 生成物 | D-Pantolactone | HCID 439368 | — |
反応手順
The aqueous phase (21 ml; Na L-pantoate) was adjusted to pH 1 with about 5 ml of 3 M H2SO4, heated at 80° C. for 15 min and mixed with 8 g of anhydrous Na2SO4. The resulting L-pantolactone was analogously extracted 3× with one volume of ethyl acetate, dried with Na2SO4 and evaporated. For recycling to the hydrolysis, the L-pantolactone melt can be racemized by heating after addition of NaOH in the presence of small amounts of Na L-pantoate (180° C., 3 h).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06998258B1 |
|---|
| 出典データセット | uspto-grants-2006_02 |
|---|
| ORD ID | ord-35ee53e0531046d0821f966490bf09eb |
|---|
| 出典メモ | uspto-grants-2006_02 |
|---|
