Potassium Hydroxide → 2-Acetylhexanoic Acid
反応式
[C:1]([CH:4]([CH2:9][CH2:10][CH2:11][CH3:12])[C:5]([O:7]C)=[O:6])(=[O:3])[CH3:2].[OH-].[K+]>O1CCOCC1>[C:1]([CH:4]([CH2:9][CH2:10][CH2:11][CH3:12])[C:5]([OH:7])=[O:6])(=[O:3])[CH3:2]参加物
4
反応条件
- 温度
- 0 °C
実験手順
3.08 g (17.9 mmol) of methyl 2-acetylhexanoate (Example 14A) is dissolved in 10 ml of dioxane and cooled to 0° C. 7.00 ml of a 3.5 M potassium hydroxide solution are added with cooling. After a reaction time of 5 h, the batch is concentrated, treated with 20 ml of ethyl acetate and 20 ml of water and extracted with shaking. The water phase is recovered, cooled to 0° C. and slowly treated with 1 N hydrochloric acid until a pH of 1 is reached. The mixture is then extracted with dichloromethane. The dichloromethane phase is dried and directly reacted further without concentrating.
後処理
- temperaturewith cooling
- concentrationAfter a reaction time of 5 h, the batch is concentrated
- additiontreated with 20 ml of ethyl acetate and 20 ml of water
- extractionextracted
- customThe water phase is recovered
- temperaturecooled to 0° C.
- additionslowly treated with 1 N hydrochloric acid until a pH of 1
- extractionThe mixture is then extracted with dichloromethane
- dry with materialThe dichloromethane phase is dried
- customdirectly reacted further
- concentrationwithout concentrating
出典と根拠
- ORDレコード
- ord-5409eda4de874948a53cf7564bc55c07
- 出典データセット
- uspto-grants-2006_02
- 特許番号
- US06998402B2
反応ノート
読み込み中…