反応式
[C:1]([O:8][CH2:9][CH3:10])(=[O:7])[C:2]([O:4]CC)=O.[O-]CC.[Na+].[C:15]([Si:19]([CH3:28])([CH3:27])[O:20][CH2:21][CH2:22][CH2:23][C:24](=[O:26])[CH3:25])([CH3:18])([CH3:17])[CH3:16]>>[CH2:9]([O:8][C:1](=[O:7])[C:2](=[O:4])[CH2:25][C:24](=[O:26])[CH2:23][CH2:22][CH2:21][O:20][Si:19]([C:15]([CH3:18])([CH3:17])[CH3:16])([CH3:27])[CH3:28])[CH3:10]参加物
4
反応条件
- 温度
- 0 °C
実験手順
Diethyl oxalate (4.048 g, 37.7 mmol) was added to solid sodium ethoxide (0.472 g, 69.3 mmol) at 0° C. followed by slow addition of 5-(tert-butyl-dimethyl-silanyloxy)-pentan-2-one (1.500 g, 69.3 mmol). The resulting orange solution was stirred at 0° C. for 10 minutes and at room temperature for 3 h. Purification by flash chromatography (19:1 hexanes:EtOAc to 9:1 EtOAc:MeOH) provided the title compound (1.982 g); MS 317 (M+1).
後処理
- customPurification by flash chromatography (19:1 hexanes:EtOAc to 9:1 EtOAc:MeOH)
出典と根拠
- ORDレコード
- ord-e8f8be09dfe2461c9f7b1abe70948934
- 出典データセット
- uspto-grants-2006_02
- 特許番号
- US06998423B2
関連ノート
読み込み中…