Benzoic Acid → 2,4-Dimethylbenzophenone

HRID 890851

反応式

HRID 890851 の反応式
[C:1]([OH:9])(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:10]1([CH3:17])[CH:15]=[CH:14][CH:13]=[C:12]([CH3:16])[CH:11]=1>[Zn]>[CH3:17][C:10]1[CH:11]=[C:12]([CH3:16])[CH:13]=[CH:14][C:15]=1[C:1]([C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)=[O:9]

参加物

4

反応物 2

HCID 243Benzoic AcidHCID 7929M-Xylene

生成物 1

HCID 708312,4-Dimethylbenzophenone

試薬・触媒・溶媒 1

HCID 23994Zinc触媒

実験手順

Benzoic acid (0.31 g, 2.5 mmol), m-xylene (0.53 g, 5.0 mmol), [bmim][NTf2] (0.50 g) and M(NTf2)2 (M=Co (0.14 g, 0.25 mmol), or Zn (0.15 g, 0.25 mmol) were placed in flasks equipped with stirrers and condensers. The contents of the flask were heated under reflux (ca 140-150 ° C.) for 2 days, then cooled to room temperature. The products were analysed by gas chromatographic analysis and found to give 93 and 87% conversions (for Co and Zn bis-triflimide reactions respectively) to 2,4-dimethylbenzophenone and, it is believed to be, 2,6-dimethylbenzophenone (11:1 isomer ratio in both cases). The results show that zinc and cobalt bis-triflimide have been found to catalyse the benzoylation of m-xylene with benzoic acid. The reaction is slower that the corresponding reaction with benzoyl chloride. The catalyst was recycled and the reaction was repeated. The results of the repeat experiment are shown in Table 4.

後処理

  1. customequipped with stirrers and condensers
  2. temperatureThe contents of the flask were heated
  3. temperatureunder reflux (ca 140-150 ° C.) for 2 days

出典と根拠

ORDレコード
ord-e0bda77d3b5e4ee2ba250b316c832578
出典データセット
uspto-grants-2006_02
特許番号
US06998497B2

関連ノート

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