2-(Methylamino)ethanol → 2-[(6-Chloro-4-pyrimidinyl)(methyl)amino]-1-ethanol

HRID 890962ノート

反応式

HRID 890962 の反応式
Cl[C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[CH:4][N:3]=1.[CH3:9][NH:10][CH2:11][CH2:12][OH:13]>C(O)C.O>[Cl:8][C:6]1[N:7]=[CH:2][N:3]=[C:4]([N:10]([CH3:9])[CH2:11][CH2:12][OH:13])[CH:5]=1

参加物

5

反応物 2

HCID 80162-(Methylamino)ethanolHCID 775312,4-Dichloropyrimidine

生成物 1

HCID 222441372-[(6-Chloro-4-pyrimidinyl)(methyl)amino]-1-ethanol

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

To a solution of 14.8 g (0.1 mmol) 2,4-dichloropyrimidine in 120 ml ethanol and 20 ml water, cooled to 0° C., 11.3 g (0.15 mol) 2-(N-methylamino)ethanol is added. The resulting mixture is stirred at room temperature for ½ h., then concentrated to dryness and finally partitioned between CH2Cl2 and a NaHCO3 saturated solution.

後処理

  1. concentrationconcentrated to dryness
  2. customfinally partitioned between CH2Cl2

出典と根拠

ORDレコード
ord-70a63d92fb7a4610b97f042a7ecb205c
出典データセット
uspto-grants-2006_02
特許番号
US07001910B1

反応ノート

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