4-Fluorophenylboronic acid → HCID 22244631、化合物

反応式

I[C:2]1[C:3]([CH3:17])=[N:4][N:5]([C:8]2[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][OH:16])=[CH:10][CH:9]=2)[C:6]=1[CH3:7].[F:18][C:19]1[CH:24]=[CH:23][C:22](B(O)O)=[CH:21][CH:20]=1>>[F:18][C:19]1[CH:24]=[CH:23][C:22]([C:2]2[C:3]([CH3:17])=[N:4][N:5]([C:8]3[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][OH:16])=[CH:10][CH:9]=3)[C:6]=2[CH3:7])=[CH:21][CH:20]=1

参加物

反応物 2

HCID 2856454-Fluorophenylboronic acid

HCID 222445592-[4-(4-Iodo-3,5-dimethyl-1H-pyrazol-1-yl)phenyl]ethanol

生成物 1

HCID 22244631HCID 22244631、化合物

実験手順

The title compound was prepared according to the procedure described in step 1 of Example 12 from 2-[4-(4-iodo-3,5-dimethyl-1H-pyrazol-1-yl)phenyl]ethanol (step 2 of Example 11) and 4-fluorobenzeneboronic acid: MS (ESI) m/z 306 [M+H]+, 1H-NMR (CDCl3) δ 7.44-7.02 (8H, m), 3.89 (2H, t, J=6.6 Hz), 2.93 (2H, t, J=6.6 Hz), 2.30(3H, s), 2.27 (3H, s).

出典と根拠

ORDレコード: ord-64582ea3577d48a086bc74216073bbf3
出典データセット: uspto-grants-2006_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07001917B2

反応ノート

読み込み中…

参加物