Chlorine → 4-Chloro-6-(2-Fluoropropan-2-Yl)-1,3,5-Triazin-2-Amine

HRID 891217ノート

反応式

HRID 891217 の反応式
[Cl:1]Cl.[NH2:3][C:4]1[N:9]=[C:8](SC)[N:7]=[C:6]([C:12]([F:15])([CH3:14])[CH3:13])[N:5]=1>C(O)(=O)C>[NH2:3][C:4]1[N:9]=[C:8]([Cl:1])[N:7]=[C:6]([C:12]([F:15])([CH3:14])[CH3:13])[N:5]=1

参加物

4

反応物 2

HCID 24526ChlorineHCID 112757034-(1-Fluoro-1-methylethyl)-6-(methylthio)-1,3,5-triazin-2-amine

生成物 1

HCID 114468284-Chloro-6-(2-Fluoropropan-2-Yl)-1,3,5-Triazin-2-Amine収率 80%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
20 °C

実験手順

Chlorine gas was passed at 20 to 25° C. into a suspension of 150 g of 2-amino-4-methylthio-6-(1-fluoroisopropyl)-1,3,5-triazine in 1 liter of glacial acetic acid (15 min). The reaction mixture was stirred for 30 min at approx. 20° C., flushed with nitrogen gas for 1 h at room temperature, poured into 5 liters of ice-cold aqueous solution of 350 g of sodium hydroxide and stirred for 5 min. After filtration with suction and drying, 110 g (80%) of 2-amino-4-chloro-6-(1-fluoroisopropyl)-1,3,5-triazine were obtained as a white powder (m.p. 185° C.).

後処理

  1. customflushed with nitrogen gas for 1 h at room temperature
  2. additionpoured into 5 liters of ice-cold aqueous solution of 350 g of sodium hydroxide
  3. stirringstirred for 5 min
  4. filtrationAfter filtration with suction
  5. customdrying

出典と根拠

ORDレコード
ord-901473c1e11549a0abac5470f10abff1
出典データセット
uspto-grants-2006_02
特許番号
US07002011B1

反応ノート

読み込み中…