化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Cyanide → Methyl 6-amino-1,3-benzodioxole-5-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Cyanide | HCID 8929 | — |
| 反応物 | 6-Nitro-1,3-benzodioxole-5-carboxaldehyde | HCID 12840 | — |
| 反応物 | 1,3-Benzodioxole-5-carboxylic acid, 6-nitro-, methyl ester | HCID 69758 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 触媒 | HCID 178418406 | HCID 178418406 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | Methyl 6-amino-1,3-benzodioxole-5-carboxylate | HCID 290838 | — |
反応手順
3,4-Methylenedioxy-6-nitrobenzaldehyde is converted to methyl 3,4-methylenedioxy-6-nitrobenzoate in methanol in the presence of sodium cyanide and manganese dioxide (Synthetic Commun., 27(7), 1281–1283 (1997)). Methyl 3,4-methylenedioxy-6-nitrobenzoate is hydrogenated in ethanol in the presence of palladium, 10% on carbon powder, at room temperature and atmospheric pressure to give methyl 3,4-methylenedioxy-6-amino-benzoate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07002022B2 |
| 出典データセット | uspto-grants-2006_02 |
| ORD ID | ord-ceeee743870d4098918b30efb5a143e5 |
| 出典メモ | uspto-grants-2006_02 |