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4-Fluorophenylboronic acid → HCID 21933850、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Fluorophenylboronic acid | HCID 285645 | — |
| 反応物 | 4-Chloro-5-methoxy-2-phenyl-3(2H)-pyridazinone | HCID 349842 | — |
| 生成物 | HCID 21933850 | HCID 21933850 | 96% |
反応手順
The 2-phenyl-4-chloro-5-methoxy-3(2H)-pyridazinone product was coupled with 4-fluorophenylboronic acid according to the method of Example 6 to provide 2-phenyl-4-(4-fluorophenyl)-5-methoxy-3(2H)-pyridazinone (yield: 1.1 g; 96%). 1H NMR (300 MHz, CDCl3) δ 4.00 (s, 3H), 7.10 (t, J=9 Hz, 2H), 7.45 (m, 3H), 7.60 (m, 4H), 8.06 (s, 1H). MS (DCI/NH3) m/z 297 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07001895B2 |
| 出典データセット | uspto-grants-2006_02 |
| ORD ID | ord-8c4fe966344145fbb7521257ec54c6f4 |
| 出典メモ | uspto-grants-2006_02 |