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Ammonia → HCID 10118077、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | Benzene, 1-iodo-3-(trifluoromethyl)- | HCID 67868 | — |
| 反応物 | 4-(4-chlorophenyl)-5-[4-(methylsulfonyl)phenyl]-3(2H)-pyridazinone | HCID 21934129 | — |
| 生成物 | HCID 10118077 | HCID 10118077 | — |
反応手順
The title compound was prepared according to Example 93, starting with 4-(4-chlorophenyl)-5-[4-(methylsulfonyl)phenyl]-3(2H)-pyridazinone in place of 4-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]-3(2H)-pyridazinone and substituting 3-iodobenzotrifluoride in place of 4-bromothioanisole (yield: 210 mg, 59.5%). mp 103-105° C. 1H NMR (300 MHz, CDCl3) δ 3.08 (s, 3H), 7.18 (d, J=9 Hz, 2H), 7.28 (d, J=9 Hz, 2H), 7.41 (d, J=9 Hz, 2H), 7.65 (m, 2H), 7.95 (m, 3H), 8.04 (m, 2H). MS (DCI/NH3) m/z 505 (M+H)+, 525 (M+NH4)+. Anal. calc. for C24H16ClF3N2O3S: C, 57.14; H, 3.17; N, 5.56. Found: C, 56.61; H, 3.28; N, 5.38.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07001895B2 |
| 出典データセット | uspto-grants-2006_02 |
| ORD ID | ord-52800ce513a24cd5a3378f97747f4804 |
| 出典メモ | uspto-grants-2006_02 |