Isobutanol → 2-(3-Chlorophenyl)-4-(2-methylpropoxy)-5-bromo-3(2H)-pyridazinone

反応式

[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[C:13](=[O:14])[C:12](Br)=[C:11]([Br:16])[CH:10]=[N:9]2)[CH:5]=[CH:6][CH:7]=1.[CH3:17][CH:18]([CH3:21])[CH2:19][OH:20]>>[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[C:13](=[O:14])[C:12]([O:20][CH2:19][CH:18]([CH3:21])[CH3:17])=[C:11]([Br:16])[CH:10]=[N:9]2)[CH:5]=[CH:6][CH:7]=1

参加物

反応物 2

HCID 6560Isobutanol

HCID 219340284,5-Dibromo-2-(3-chlorophenyl)pyridazin-3(2H)-one

生成物 1

HCID 219338642-(3-Chlorophenyl)-4-(2-methylpropoxy)-5-bromo-3(2H)-pyridazinone

実験手順

The title compound was prepared according to the method of Example 194B, starting with 2-(3-chlorophenyl)-4,5-dibromo-3(2H)-pyridazinone (Example 207A) in place of 2-(4-fluorophenyl)-4,5-dibromo-3(2H)-pyridazinone and substituting 2-methyl-1-propanol in place of methanol.

出典と根拠

ORDレコード: ord-61199daeaa7e45ee90563c9b7f5f486f
出典データセット: uspto-grants-2006_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07001895B2

反応ノート

読み込み中…