Hydrochloric Acid → N~2~-Propan-2-ylglycinamide--hydrogen chloride (1/1)

HRID 891706ノート

反応式

HRID 891706 の反応式
C(OC(=O)[N:7]([CH2:11][C:12](=[O:14])[NH2:13])[CH:8]([CH3:10])[CH3:9])(C)(C)C.[ClH:16].C(OCC)C>O1CCOCC1>[ClH:16].[CH:8]([NH:7][CH2:11][C:12]([NH2:13])=[O:14])([CH3:10])[CH3:9]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 62544165HCID 62544165、化合物

生成物 1

HCID 16243660N~2~-Propan-2-ylglycinamide--hydrogen chloride (1/1)収率 97%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒2 回

実験手順

To a solution of N-carbamoylmethyl-N-isopropyl-carbamic acid t-butyl ester (2.67 g, 12.3 mmol) (obtained as described in Reference Example 49(1)) in 1,4-dioxane (30 ml) was added a solution of 4N hydrogen chloride in 1,4-dioxane (30 ml) in an ice bath, and then the mixture was stirred at room temperature overnight. After checking the completion of the reaction, diethyl ether was added thereto and the reaction mixture was stirred for 30 minutes. The resulting mixture was filtered, and the residue was washed with diethyl ether and then dried under reduced pressure to give 2-isopropylaminoacetamide hydrochloride (1.82 g, yield 97%) as white crystals.

後処理

  1. additionwas added
  2. stirringthe reaction mixture was stirred for 30 minutes
  3. filtrationThe resulting mixture was filtered
  4. washthe residue was washed with diethyl ether
  5. customdried under reduced pressure

出典と根拠

ORDレコード
ord-579c2296d911401ebe0bc54fd581ec40
出典データセット
uspto-grants-2006_02
特許番号
US07001897B2

反応ノート

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