5-Chloro-3-(2-methylimidazol-1-ylmethyl)-pyridazine → 5-(3-tert-Butyl-phenyl)-3-(2-methyl-imidazol-1-yl-methyl)-pyridazine Hydrochloride

反応式

[C:1]([C:5]1[CH:6]=[C:7](B2OC(C)(C)C(C)(C)O2)[CH:8]=[CH:9][CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[Cl:20][C:21]1[CH:22]=[C:23]([CH2:27][N:28]2[CH:32]=[CH:31][N:30]=[C:29]2[CH3:33])[N:24]=[N:25][CH:26]=1>>[ClH:20].[C:1]([C:5]1[CH:6]=[C:7]([C:21]2[CH:22]=[C:23]([CH2:27][N:28]3[CH:32]=[CH:31][N:30]=[C:29]3[CH3:33])[N:24]=[N:25][CH:26]=2)[CH:8]=[CH:9][CH:10]=1)([CH3:2])([CH3:3])[CH3:4]

参加物

反応物 2

HCID 117890255-Chloro-3-(2-methylimidazol-1-ylmethyl)-pyridazine

HCID 222401372-(3-(tert-Butyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

生成物 1

HCID 222402415-(3-tert-Butyl-phenyl)-3-(2-methyl-imidazol-1-yl-methyl)-pyridazine Hydrochloride

実験手順

The title compound, MS: m/e=307.3 (M+H+), was prepared from 2-(3-tert-butylphenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane and 5-chloro-3-(2-methyl-imidazol-1-yl-methyl)-pyridazine.

出典と根拠

ORDレコード: ord-4c8969f08a5247a29078330c343286ba
出典データセット: uspto-grants-2006_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07005432B2

反応ノート

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