p-Toluenesulfonic acid monohydrate → 3-(2-Quinolin-2-yl-vinyl)-phenol

HRID 892143ノート

反応式

HRID 892143 の反応式
COCCOC[O:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([CH:14]=[CH:15][C:16]2[CH:25]=[CH:24][C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[N:17]=2)[CH:9]=1.O.C1(C)C=CC(S(O)(=O)=O)=CC=1>>[N:17]1[C:18]2[C:23](=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:24]=[CH:25][C:16]=1[CH:15]=[CH:14][C:10]1[CH:9]=[C:8]([OH:7])[CH:13]=[CH:12][CH:11]=1

参加物

3

反応物 2

HCID 521998p-Toluenesulfonic acid monohydrateHCID 544075821-(2-Methoxyethoxy)-methoxy-3-(2-quinolin-2-yl-vinyl)-benzene

生成物 1

HCID 48788413-(2-Quinolin-2-yl-vinyl)-phenol

反応条件

温度
60 °C

実験手順

To a solution of 1-(2-methoxyethoxy)-methoxy-3-(2-quinolin-2-yl-vinyl)-benzene (120 mg, 0.35 mmol, example 16) is added p-toluene sulphonic acid monohydrate. (74 mg, 0.39 mmol). The resulting solution is heated to 60° C. and stirred at this temperature for 4 h. The reaction mixture is then cooled, concentrated and the residue taken up in dichloromethane. This solution is washed with sat. NaHCO3 solution, dried over MgSO4 then concentrated to give the title compound as a solid. MS (ESI) 248 (M+H)+.

後処理

  1. temperatureThe reaction mixture is then cooled
  2. concentrationconcentrated
  3. washThis solution is washed with sat. NaHCO3 solution
  4. dry with materialdried over MgSO4
  5. concentrationthen concentrated

出典と根拠

ORDレコード
ord-9e6fd853a2dc49e28aaf2c784df32eee
出典データセット
uspto-grants-2006_02
特許番号
US07005440B1

反応ノート

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