Water → 5-Chloro-2-hydroxy-3-methoxybenzaldehyde

HRID 892173

反応式

HRID 892173 の反応式
S(Cl)([Cl:4])(=O)=O.[O:6]=[CH:7][C:8]1[CH:16]=[CH:15][CH:14]=[C:11]([O:12][CH3:13])[C:9]=1[OH:10].O>C1(C)C=CC=CC=1>[Cl:4][C:15]1[CH:14]=[C:11]([O:12][CH3:13])[C:9]([OH:10])=[C:8]([CH:16]=1)[CH:7]=[O:6]

参加物

5

反応物 3

HCID 962WaterHCID 8991o-VanillinHCID 24648Sulfuryl chloride

生成物 1

HCID 51510865-Chloro-2-hydroxy-3-methoxybenzaldehyde

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒2 回

実験手順

A solution of sulfuryl chloride (15 mL, 190 mmol) in toluene (20 mL) is added dropwise over 1.5 h to a solution of o-vanillin (25.0 g, 164 mmol) in toluene (90 mL) and the reaction is then stirred 16 h. Water (30 mL) is added over 10 minutes with ice-bath cooling. The solid is filtered, washed with water and dried to provide the title compound. MS (EI) 186 (M)+.

後処理

  1. temperaturecooling
  2. filtrationThe solid is filtered
  3. washwashed with water
  4. customdried

出典と根拠

ORDレコード
ord-17aa28f080b149d99a1ef1821d5e4992
出典データセット
uspto-grants-2006_02
特許番号
US07005440B1

関連ノート

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