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Methyl 3-(3,5-dibromo-4-hydroxyphenyl)propionate → 3-[3,5-Dibromo-4-(3-hydroxybenzyloxy)phenyl]propionic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl 3-(3,5-dibromo-4-hydroxyphenyl)propionate | HCID 624213 | — |
| 反応物 | 3-(Bromomethyl)phenyl acetate | HCID 6422075 | — |
| 生成物 | 3-[3,5-Dibromo-4-(3-hydroxybenzyloxy)phenyl]propionic acid | HCID 22242281 | 78% |
反応手順
Methyl 3-(3,5-dibromo-4-hydroxyphenyl)propionate (0.15 g, 0.44 mmol) was coupled with 3-bromomethylphenyl acetate (0.20 g, 0.88 mmol) using the procedure described in Method D4. Purification on column (silica gel, dichloromethane/methanol, gradient elution from 95:5 to 90:10) gave 123 mg (78%) of 3-[3,5-dibromo-4-(3-hydroxybenzyloxy)phenyl]propionic acid. MS: m/z 430.1 (M+−1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07005538B1 |
| 出典データセット | uspto-grants-2006_02 |
| ORD ID | ord-9ad7dd7d3d274059adbe6e110601dd73 |
| 出典メモ | uspto-grants-2006_02 |