Diethyl Ether → HCID 135537121、化合物

HRID 892435ノート

反応式

HRID 892435 の反応式
Cl[C:2]1[CH:7]=[C:6]([OH:8])[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[O:15][CH2:16][CH2:17][CH3:18])[N:3]=1.[CH2:19]([NH2:21])[CH3:20].C(OCC)C>C(O)C>[CH2:19]([NH:21][C:2]1[N:3]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[O:15][CH2:16][CH2:17][CH3:18])[NH:5][C:6](=[O:8])[CH:7]=1)[CH3:20]

参加物

5

反応物 3

HCID 3283Diethyl EtherHCID 6341EthylamineHCID 178458304HCID 178458304、化合物

生成物 1

HCID 135537121HCID 135537121、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

4-Chloro-6-hydroxy-2-(2-propoxyphenyl)pyrimidine (0.66 g) and ethylamine in ethanol (33%, 20 ml) was heated at 90° C. in a pressure vessel for 16 hours. The cooled reaction mixture was evaporated under reduced pressure to yield an oil which solidified on trituration with diethyl ether. The residue was recrystallised from isopropanol: diethyl ether, washed with water and recrystallised from isopropanol:water to yield the title compound, 0.47 g, m.p. 187°-8° C.

後処理

  1. customThe cooled reaction mixture
  2. customwas evaporated under reduced pressure
  3. customto yield an oil which
  4. customThe residue was recrystallised from isopropanol
  5. washdiethyl ether, washed with water
  6. customrecrystallised from isopropanol

出典と根拠

ORDレコード
ord-f17bc6c8a5b247e5bbd9ece180c9a8b2
出典データセット
uspto-grants-1992_06
特許番号
US05118686

反応ノート

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