Propylamine → HCID 135537129、化合物

HRID 892436ノート

反応式

HRID 892436 の反応式
Cl[C:2]1[CH:7]=[C:6]([OH:8])[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[O:15][CH2:16][CH2:17][CH3:18])[N:3]=1.[CH2:19]([NH2:22])[CH2:20][CH3:21]>C(O)C>[CH2:19]([NH:22][C:2]1[N:3]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[O:15][CH2:16][CH2:17][CH3:18])[NH:5][C:6](=[O:8])[CH:7]=1)[CH2:20][CH3:21]

参加物

4

反応物 2

HCID 7852PropylamineHCID 178458304HCID 178458304、化合物

生成物 1

HCID 135537129HCID 135537129、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

4-Chloro-6-hydroxy-2-(2-propoxyphenyl)pyrimidine (0.66 g), n-propylamine (1.8 g) and ethanol (20 ml) was heated at 90° C. in a pressure vessel for 16 hours. The cooled reaction mixture was evaporated under reduced pressure to lo yield an oil which solidified on washing with water. The residue was recrystallised from isopropanol: water to yield the title compound, 0.56 g, m.p. 172°-3° C.

後処理

  1. customThe cooled reaction mixture
  2. customwas evaporated under reduced pressure
  3. customto lo yield an oil which
  4. washon washing with water
  5. customThe residue was recrystallised from isopropanol

出典と根拠

ORDレコード
ord-e0be2acdc011471a9a345b38f6d44286
出典データセット
uspto-grants-1992_06
特許番号
US05118686

反応ノート

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