HCID 19895618、化合物 → HCID 19895692、化合物

HRID 892511ノート

反応式

HRID 892511 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]([C:14]1[C:19]([CH3:20])=[CH:18][CH:17]=[CH:16][N:15]=1)(O)[CH:9]=[C:10]([CH3:12])[CH3:11]>COCCOCCOC>[CH3:11][C:10]1([CH3:12])[CH:9]=[C:8]([C:14]2[C:19]([CH3:20])=[CH:18][CH:17]=[CH:16][N:15]=2)[C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[O:1]1

参加物

3

反応物 1

HCID 19895618HCID 19895618、化合物

生成物 1

HCID 19895692HCID 19895692、化合物収率 70.7%

試薬・触媒・溶媒 1

HCID 8150Diglyme溶媒

実験手順

4.5 g of 1-(2-hydroxyphenyl)-3-methyl-1-(3-methyl-2-pyridyl)-2-buten-1-ol were dissolved in 50 ml of diethylene glycol dimethyl ether and heated at reflux for 1 hour. The mixture was allowed to cool to room temperature and then evaporated. The residue was chromatographed on silica gel using ethyl acetate/petroleum ether (1:4) and then ethyl acetate/petroleum ether (1:2) for the elution to give 2.97 g of 2,2-dimethyl-4-(3-methyl-2-pyridyl)-2H-1-benzopyran in the form of an oil.

後処理

  1. temperatureheated
  2. temperatureat reflux for 1 hour
  3. customevaporated
  4. customThe residue was chromatographed on silica gel
  5. washethyl acetate/petroleum ether (1:2) for the elution

出典と根拠

ORDレコード
ord-61ae6c30b5a54fcfb3d6e54f7e66eec6
出典データセット
uspto-grants-1992_06
特許番号
US05118694

反応ノート

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