Benzyl Bromide → S-benzylthiobenzimidate hydrobromide

HRID 8927

反応式

HRID 8927 の反応式
[C:1]([NH2:9])(=[S:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:10]([Br:17])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C(Cl)Cl>[BrH:17].[CH2:10]([S:8][C:1](=[NH:9])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

参加物

4

反応物 2

HCID 7498Benzyl BromideHCID 683563Thiobenzamide

生成物 1

HCID 12624654S-benzylthiobenzimidate hydrobromide収率 85%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of thiobenzamide (0.307 g, 2.24 mmol) in CH2Cl2 (11 mL) was added benzyl bromide (0.26 mL, 2.19 mmol) and the resultant solution was heated to reflux for 2 h. The mixture was cooled to room temperature and concentrated under reduced pressure. The resultant yellow solid was dried under vacuum to provide S-benzylthiobenzimidate hydrobromide (0.573 g, 85%). 1H NMR (DMSO-d6) δ 4.76 (s, 2H), 7.34–7.44 (m, 3H), 7.51–7.54 (m, 2H), 7.61–7.66 (m, 2H), 7.78–7.83 (m, 1H), 7.88–7.91 (m, 2H), 11.92 (br s, 1H).

後処理

  1. temperatureto reflux for 2 h
  2. concentrationconcentrated under reduced pressure
  3. customThe resultant yellow solid was dried under vacuum

出典と根拠

ORDレコード
ord-8753c4924bb442778d438b5dc7c0fe64
出典データセット
uspto-grants-2006_08
特許番号
US07091217B2

関連ノート

読み込み中…