Benzyl Bromide → 2-Benzyloxy-5-phenoxybenzaldehyde

HRID 892845ノート

反応式

HRID 892845 の反応式
[O:1]([C:8]1[CH:9]=[CH:10][C:11]([OH:16])=[C:12]([CH:15]=1)[CH:13]=[O:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:23](Br)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>CN(C=O)C.C(OCC)(=O)C>[CH2:23]([O:16][C:11]1[CH:10]=[CH:9][C:8]([O:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[CH:15][C:12]=1[CH:13]=[O:14])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

参加物

6

反応物 3

HCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 149712582-Hydroxy-5-phenoxybenzaldehyde

生成物 1

HCID 104477522-Benzyloxy-5-phenoxybenzaldehyde

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒HCID 8857Ethyl Acetate溶媒

実験手順

5-Phenoxy-2-hydroxybenzaldehyde (20 g, 94 mmol) and potassium carbonate (26.1 g, 188 mmol) are taken up in DMF (250 mL) and treated with benzyl bromide (16.1 g, 94 mmol). The mixture is stirred at room temperature overnight. The mixture is diluted with ethyl acetate and washed three times with saturated aqueous ammonium chloride, dried over magnesium sulfate and evaporated to give 2-benzyloxy-5-phenoxybenzaldehyde as a colorless solid. This is used without further purification.

後処理

  1. washwashed three times with saturated aqueous ammonium chloride
  2. dry with materialdried over magnesium sulfate
  3. customevaporated

出典と根拠

ORDレコード
ord-8867b9d0b3334aae9bbc167c1acc113c
出典データセット
uspto-grants-1992_06
特許番号
US05120758

反応ノート

読み込み中…