Hydrogen Peroxide → 2-Benzyloxy-5-phenoxyphenol

HRID 892846ノート

反応式

HRID 892846 の反応式
[CH2:1]([O:8][C:9]1[CH:16]=[CH:15][C:14]([O:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[CH:13][C:10]=1C=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.OO.S(=O)(=O)(O)[OH:27]>CO>[CH2:1]([O:8][C:9]1[CH:16]=[CH:15][C:14]([O:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[CH:13][C:10]=1[OH:27])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 784Hydrogen PeroxideHCID 1118Sulfuric AcidHCID 104477522-Benzyloxy-5-phenoxybenzaldehyde

生成物 1

HCID 152014472-Benzyloxy-5-phenoxyphenol

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

2-Benzyloxy-5-phenoxybenzaldehyde (22.25 g, 73 mmol) is dissolved in methanol (200 mL) and treated with hydrogen peroxide (31% in water, 32.0 mL) and concentrated sulfuric acid (15.0 mL). The mixture is stirred overnight at room temperature and evaporated. The residue is dissolved in saturated aqueous sodium chloride solution and extracted with ether. The organic phase is dried over magnesium sulfate and evaporated. Purification of the residue by silica-gel flash chromatography gives 2-benzyloxy-5-phenoxyphenol as a colorless solid.

後処理

  1. customevaporated
  2. dissolutionThe residue is dissolved in saturated aqueous sodium chloride solution
  3. extractionextracted with ether
  4. dry with materialThe organic phase is dried over magnesium sulfate
  5. customevaporated
  6. customPurification of the residue by silica-gel flash chromatography

出典と根拠

ORDレコード
ord-7f3d9d13f8b94dafb22414c9a40c28e8
出典データセット
uspto-grants-1992_06
特許番号
US05120758

反応ノート

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