1,2,3,4-Tetrahydro-1-methylquinoline → 1,2,3,4-Tetrahydroquinoline

HRID 893061

反応式

HRID 893061 の反応式
Cl.C[N:3]1[C:12]2[C:7](=[CH:8][C:9](N=O)=[CH:10][CH:11]=2)[CH2:6][CH2:5][CH2:4]1.CN1C2C(=CC=CC=2)CCC1>>[NH:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6][CH2:5][CH2:4]1

参加物

3

反応物 2

HCID 681091,2,3,4-Tetrahydro-1-methylquinolineHCID 190990131-Methyl-6-nitroso-1,2,3.4-tetrahydroquinoline hydrochloride

生成物 1

HCID 694601,2,3,4-Tetrahydroquinoline

実験手順

1-methyl-6-nitroso-1,2,3.4-tetrahydroquinoline hydrochloride ##STR25## The title compound is prepared from 1-methyl1,2,3,4-tetrahydroquinoline (obtained from 1,2,3,4tetrahydroquinoline by heating with trimethylphosphate (according to Huisgen et al., Chem. Ber. 92, 203 (1959)). The crude product is produced in the usual manner analogous to Examples 10 and 11 and purified on silica gel 60 (Merck) with isopropanol/n-butylacetate/water=5:3:2. The title compound is obtained by dissolving this in acetone after addition of ethereal hydrochloric acid, m.p. 123°-124° C. (decomp.), TLC: silica gel 60, mobile phase: isopropanol/n-butylacetate/water=5:3:2, Rf =0.7.

出典と根拠

ORDレコード
ord-dae7ceedec2d48afba15df48ed72fbf0
出典データセット
uspto-grants-1992_06
特許番号
US05122244

関連ノート

読み込み中…