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O-methyl hydrazinecarbothioate → 5-[2-(4-acetamidophenyl)ethanyl]-5,6-dihydro-1,3,4-thiadiazin-2(3H)one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | O-methyl hydrazinecarbothioate | HCID 10171237 | — |
| 反応物 | 1-Chloro-4-(4-acetamidophenyl)-2-oxo-3-butene | HCID 54055357 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 5-[2-(4-acetamidophenyl)ethanyl]-5,6-dihydro-1,3,4-thiadiazin-2(3H)one | HCID 19892759 | — |
反応手順
A mixture containing 4.0 g of 1-chloro-4-(4-acetamidophenyl)-2-oxo-3-butene (J. Org. Chem., 28, 2446, 1963) and 2.3 g of hydrazinecarbothioic acid O-methylester in 150 ml of toluene was refluxed for 3 h. The crystals were filtered and washed with toluene. Yield 3.0 g (65%), mp. 235°-240° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05122524 |
| 出典データセット | uspto-grants-1992_06 |
| ORD ID | ord-65cfd78dde2b431692ae86f4e96337a8 |
| 出典メモ | uspto-grants-1992_06 |