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Potassium Carbonate → N-(2-butenyl)-N-(4-chloro-3-isopropylphenyl)-2-chloro-2-(3-fluorophenyl)acetamide

HRID 893187
ノート
印刷プレビュー

反応式

HRID 893187 の反応式
[Cl:1][CH:2]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([F:12])[CH:7]=1)[C:3](Cl)=[O:4].[CH2:13]([NH:17][C:18]1[CH:23]=[CH:22][C:21]([Cl:24])=[C:20]([CH:25]([CH3:27])[CH3:26])[CH:19]=1)[CH:14]=[CH:15][CH3:16].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH2:13]([N:17]([C:18]1[CH:23]=[CH:22][C:21]([Cl:24])=[C:20]([CH:25]([CH3:27])[CH3:26])[CH:19]=1)[C:3](=[O:4])[CH:2]([Cl:1])[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([F:12])[CH:7]=1)[CH:14]=[CH:15][CH3:16]
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 198914902-Chloro-2-(3-fluorophenyl)acetyl chlorideHCID 54500563N-(2-butenyl)-N-(4-chloro-3-isopropylphenyl)amine

生成物 1

HCID 54355070N-(2-butenyl)-N-(4-chloro-3-isopropylphenyl)-2-chloro-2-(3-fluorophenyl)acetamide

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

2.6 g of 2-chloro-2-(3-fluorophenyl)acetyl chloride were gradually added dropwise to 2.2 g of N-(2-butenyl)-N-(4-chloro-3-isopropylphenyl)amine and 2.0 g of anhydrous potassium carbonate in 40 ml of N,N-dimethylformamide with stirring at 20°-30° C. After the stirring was additionally continued for 20 minutes, potassium carbonate was removed by filtration, and extraction was then carried out with toluene. After drying over anhydrous sodium sulfate, the reaction solution was concentrated by means of an evaporator to quantitatively obtain the desired oily product.

後処理

  1. custompotassium carbonate was removed by filtration, and extraction
  2. dry with materialAfter drying over anhydrous sodium sulfate
  3. concentrationthe reaction solution was concentrated by means of an evaporator
  4. customto quantitatively obtain the desired oily product

出典と根拠

ORDレコード
ord-211ba34586764a49a4b4afa93feb9e93
出典データセット
uspto-grants-1992_06
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US05123954

反応ノート

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