反応式
[CH3:1][CH2:2][CH2:3][C:4]#[C:5][CH2:6][CH2:7][CH3:8].[N+](=[C:11]([C:16]([O:18][CH3:19])=[O:17])[C:12]([O:14][CH3:15])=[O:13])=[N-]>CC(CC(C)=O)=O.CC(CC(C)=O)=O.[Cu]>[CH2:3]([C:4]1[C:11]([C:16]([O:18][CH3:19])=[O:17])([C:12]([O:14][CH3:15])=[O:13])[C:5]=1[CH2:6][CH2:7][CH3:8])[CH2:2][CH3:1]参加物
4
実験手順
4-Octyne and dimethyl diazomalonate were reacted in the presence of cupric acetylacetonate in a manner similar to that described in Example XCVII Part A to give dimethyl 2,3-di-n-propyl-2-cyclopropene-1,1-dicarboxylate which was saponified to give mono-methyl 2,3-di-n-propyl-2-cyclopropene-1,1-dicarboxylate and worked up by the general procedure of Example XCVII Part B. Reaction of the latter mono-methyl ester in sequence with ethyl chloroformate and 4-bromo-2-methylaniline, in the presence of potassium carbonate and 18-crown-6, in a manner similar to that described in Example XCIX Part B to give methyl 1-(4-bromo-2-methylphenyl-aminocarbonyl)-2,3-di-n-propyl-2-cyclopropenecarboxylate having a melting point of 52° C.-54° C.
出典と根拠
- ORDレコード
- ord-12686ffa579a400cb8108ef63f7686b4
- 出典データセット
- uspto-grants-1992_06
- 特許番号
- US05123951
関連ノート
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