Acetic Acid → Diisopropylether methanol

HRID 893343

反応式

HRID 893343 の反応式
CC1C=C2[C:8](=[CH:9][CH:10]=1)N[C:6](=[O:11])C2.[CH3:12][C:13]([O-:15])=O.[Na+].[C:17](O)(=O)C>>[CH3:6][OH:11].[O:15]([CH:9]([CH3:8])[CH3:10])[CH:13]([CH3:12])[CH3:17]

参加物

4

反応物 3

HCID 176Acetic AcidHCID 517045Sodium AcetateHCID 53257165-Methylindolin-2-one

生成物 1

HCID 21882575Diisopropylether methanol

実験手順

A mixture of 5-methyl-2-oxindole (2.94 g, 0.02 mol), 3,5-di-tertiary-butyl-4-hydroxybenzoldehyde (4.68 g, 0.02 mol), and anyydrous NaOAc (5.75 g, 0.07 mol) in glacial acetic acid (100 mL) was heated to reflux for 18 hours. The cooled reaction mixture was poured into ice-water mixture when a yellow product precipitated out. It was recrystallized from CH2Cl2 --CH3OH-iso-Pr2O to give the analytical sample. Yield 2.16 g (28.7%), mp 230°-234° C.

後処理

  1. temperaturewas heated
  2. temperatureto reflux for 18 hours
  3. customThe cooled reaction mixture
  4. customprecipitated out
  5. customIt was recrystallized from CH2Cl2

出典と根拠

ORDレコード
ord-9e9feb137dcb4903abe56920c948ff41
出典データセット
uspto-grants-1992_06
特許番号
US05124347

関連ノート

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