Hydrogen Peroxide → 5-Ethynyl-1-pentofuranosyl-1H-imidazole-4-carboximidic acid

HRID 893706ノート

反応式

HRID 893706 の反応式
[C:1]([C:3]1[N:7]([C@@H:8]2[O:14][C@H:13]([CH2:15][OH:16])[C@@H:11]([OH:12])[C@H:9]2[OH:10])[CH:6]=[N:5][C:4]=1[C:17]#[N:18])#[CH:2].[OH:19]O>N.CO>[C:1]([C:3]1[N:7]([C@@H:8]2[O:14][C@H:13]([CH2:15][OH:16])[C@@H:11]([OH:12])[C@H:9]2[OH:10])[CH:6]=[N:5][C:4]=1[C:17]([NH2:18])=[O:19])#[CH:2]

参加物

5

反応物 2

HCID 784Hydrogen PeroxideHCID 11043123HCID 11043123、化合物

生成物 1

HCID 4531805-Ethynyl-1-pentofuranosyl-1H-imidazole-4-carboximidic acid

試薬・触媒・溶媒 2

HCID 222Ammonia溶媒HCID 887Methanol溶媒

実験手順

To a solution of 127 mg (0.51 mmol) of 5-ethynyl-1-β-D-ribofuranosylimidazole-4-carbonitrile dissolved in 6 ml of a solvent mixture of aqueous ammonia and methanol (1:1) was added 0.5 ml of hydrogen peroxide, and the reaction was carried out with stirring at room temperature for 45 minutes. After the reaction, the solvent was evaporated, and the residue was adsorbed onto a silica gel column and eluted with a 5 - 10% ethanolchloroform solvent mixture, and crystallized from ethanol to obtain white crystals of 5-ethynyl-1-β-D-ribofuranosylimidazole-4-carboxamide.

後処理

  1. customAfter the reaction
  2. customthe solvent was evaporated
  3. washeluted with a 5 - 10% ethanolchloroform solvent mixture
  4. customcrystallized from ethanol

出典と根拠

ORDレコード
ord-1a8a7ec297a44b34a09c6d4c8223575f
出典データセット
uspto-grants-1992_06
特許番号
US05126361

反応ノート

読み込み中…