化工社化工社 化学情報印刷レポート · 研究参考用
Ethyl chloroformate → 4-(2,3,4-Trimethoxybenzylthio)-1-cinnamylpiperidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl chloroformate | HCID 10928 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | Toluene, alpha-chloro-2,3,4-trimethoxy- | HCID 97491 | — |
| 反応物 | Sodium | HCID 5360545 | — |
| 反応物 | Fumarate | HCID 5460307 | — |
| 反応物 | 1-Methylpiperidine-4-thiol | HCID 14180391 | — |
| 反応物 | 4-(2,3,4-Trimethoxybenzylthio)-1-ethoxycarbonylpiperidine | HCID 19890907 | — |
| 反応物 | 4-(2,3,4-Trimethoxybenzylthio)-1-cinnamylpiperidine fumarate | HCID 67894540 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4-(2,3,4-Trimethoxybenzylthio)-1-cinnamylpiperidine | HCID 53752093 | — |
反応手順
The 4-(2,3,4-trimethoxybenzylthio)piperidine used as starting material, the fumarate of which melts at 154° C., was prepared by the hydrolysis, using potassium hydroxide and ethanol, of 4-(2,3,4-trimethoxybenzylthio)-1-ethoxycarbonylpiperidine (oil), which was itself prepared by the action of ClCOOC2H5 in benzene on 4-(2,3,4-trimethoxybenzylthio)-1-methylpiperidine (m.p. of the corresponding fumarate: 130° C.), which was itself prepared by the condensation of 2,3,4-trimethoxybenzyl chloride in ethanol with the sodium salt of 1-methyl-4-mercaptopiperidine, b.p./13 : 70°-72° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05126356 |
| 出典データセット | uspto-grants-1992_06 |
| ORD ID | ord-723d3b8048ee46d3b6b86ab349d9e5a4 |
| 出典メモ | uspto-grants-1992_06 |