2,5-Hexanedione → 2-(2,5-dimethyl-1H-pyrrol-1-yl)-1H-isoindole-1,3(2H)-dione

HRID 893868

反応式

HRID 893868 の反応式
[NH2:1][N:2]1[C:6](=[O:7])[C:5]2=[CH:8][CH:9]=[CH:10][CH:11]=[C:4]2[C:3]1=[O:12].[CH3:13][C:14]([CH2:16][CH2:17][C:18]([CH3:20])=O)=O>C(O)(=O)C.C(Cl)Cl>[CH3:20][C:18]1[N:1]([N:2]2[C:3](=[O:12])[C:4]3=[CH:11][CH:10]=[CH:9][CH:8]=[C:5]3[C:6]2=[O:7])[C:14]([CH3:13])=[CH:16][CH:17]=1

参加物

5

反応物 2

HCID 80352,5-HexanedioneHCID 74645N-Aminophthalimide

生成物 1

HCID 28171692-(2,5-dimethyl-1H-pyrrol-1-yl)-1H-isoindole-1,3(2H)-dione収率 98%

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 6344Dichloromethane溶媒

実験手順

A mixture of N-amino-phthalimide (50 g) and 2,5-hexadione (35.2 g) in 400 ml acetic acid was refluxed for 48 hours, stripped of solvent, slurried in methylene chloride and filtered. The filtrate was washed with saturated sodium bicarbonate solution, dried and stripped to yield N-(2,5-dimethylpyrrol-1-yl)-phthalimide (98%).

後処理

  1. temperaturewas refluxed for 48 hours
  2. filtrationfiltered
  3. washThe filtrate was washed with saturated sodium bicarbonate solution
  4. customdried

出典と根拠

ORDレコード
ord-dfc76c2b2d994cfcb531a12813a8a835
出典データセット
uspto-grants-1981_08
特許番号
US04282028

関連ノート

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