3,5-Dimethoxybenzaldehyde → 1-(3,5-Dimethoxyphenyl)-7-hydroxy-1-hepten-3-one

10 parts of the phosphonium salt produced in Example 16 was dissolved in water containing an amount of potassium carbonate in excess of that necessary to deprotonate the phosphonium chloride. After extracting this solution with methylene chloride, the organic phase was dried over sodium sulfate. After separation of the drying agent, the methylene chloride was removed at room temperature and under a stream of nitrogen, leaving (5-hydroxypentanoylmethylene)-triphenylphosphorane. 7.04 parts of this phosphorane and 3.11 parts of 3,5-dimethoxybenzaldehyde were dissolved in about 135 parts of benzene, and the solution was maintained under a nitrogen atmosphere and refluxed for 3 days. After the reaction mixture was cooled to room temperature, the benzene was removed at room temperature under a nitrogen stream, leaving a product mixture. This mixture was separated chromatographically on a silica column using as the elution solvent a mixture of 30 percent by volume of ethyl acetate in benzene, to yield 1-(3,5-dimethoxyphenyl)-7-hydroxy-1-hepten-3-one which, after recrystallization from a mixture of benzene and cyclohexane, melted at about 78°-80° C.

1. temperaturethe solution was maintained under a nitrogen atmosphere
2. temperaturerefluxed for 3 days
3. customthe benzene was removed at room temperature under a nitrogen stream
4. customleaving a product mixture
5. customThis mixture was separated chromatographically on a silica column
6. additiona mixture of 30 percent by volume of ethyl acetate in benzene

ORDレコード

ord-d5c20e2979f54c83b124dc76f495a686

出典データセット

uspto-grants-1981_08

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US04282158