Aziridine-2-carbonitrile → 1-(N-Pivaloyl-carbamoyl)-2-cyanoaziridine

HRID 893953

反応式

HRID 893953 の反応式
[C:1]([CH:3]1[CH2:5][NH:4]1)#[N:2].[CH3:6][C:7]([CH3:14])([CH3:13])[C:8]([N:10]=[C:11]=[O:12])=[O:9]>C1(C)C=CC=CC=1>[C:8]([NH:10][C:11]([N:4]1[CH2:5][CH:3]1[C:1]#[N:2])=[O:12])(=[O:9])[C:7]([CH3:14])([CH3:13])[CH3:6]

参加物

4

反応物 2

HCID 118115Aziridine-2-carbonitrileHCID 126188362,2-dimethylpropanecarbonyl isocyanate

生成物 1

HCID 211619901-(N-Pivaloyl-carbamoyl)-2-cyanoaziridine

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒2 回

実験手順

A solution of 1.61 g. 2-cyanoaziridine in 30 ml. toluene is added dropwise at 20° to 30° C. to a solution of 3 g. trimethyl-acetyl isocyanate in 40 ml. anhydrous toluene and the reaction mixture then stirred for 1 hour at ambient temperature, whereafter the milky solution obtained is evaporated in a vacuum. The evaporation residue is rubbed with a glass rod until crystallization commences and the crystals obtained are triturated with diethyl ether. There is thus obtained 1.82 g. 1-(N-pivaloyl-carbamoyl)-2-cyanoaziridine which, after drying at 60° C. in a vacuum, melts at 136°-138° C.

後処理

  1. customobtained
  2. customis evaporated in a vacuum
  3. customThe evaporation residue is rubbed with a glass rod until crystallization commences
  4. customthe crystals obtained
  5. customare triturated with diethyl ether
  6. dry with material1-(N-pivaloyl-carbamoyl)-2-cyanoaziridine which, after drying at 60° C. in a vacuum, melts at 136°-138° C.

出典と根拠

ORDレコード
ord-69a3eebbbf4242b8a35f6ee3198d8067
出典データセット
uspto-grants-1981_08
特許番号
US04282212

関連ノート

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