Aziridine-2-carbonitrile → HCID 21161947、化合物
反応式
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([N:8]=[C:9]=[O:10])=[O:7].[C:11]([CH:13]1[CH2:15][NH:14]1)#[N:12]>C1(C)C=CC=CC=1>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([NH:8][C:9]([N:14]1[CH2:15][CH:13]1[C:11]#[N:12])=[O:10])=[O:7]参加物
4
実験手順
2.76 g. Thiophene-2-carbonyl isocyanate are dissolved in 45 ml. anhydrous toluene and mixed dropwise, while stirring, at 20° to 30° C. with a solution of 1.22 g. 2-cyanoaziridine in 30 ml. toluene. Stirring is continued for 1 hour at ambient temperature and the precipitate obtained is filtered off with suction, washed with toluene and subsequently triturated with diethyl ether. There are thus obtained 3.4 g. 1-(N-2-thiophene-carbonyl-carbamoyl)-2-cyanoaziridine; m.p. 156°-160° C., which still contains a little thiophene-2-carboxylic acid amide.
後処理
- stirringStirring
- customthe precipitate obtained
- filtrationis filtered off with suction
- washwashed with toluene
- customsubsequently triturated with diethyl ether
出典と根拠
- ORDレコード
- ord-86125920b2814ee88f415d6ae0b6b6b5
- 出典データセット
- uspto-grants-1981_08
- 特許番号
- US04282212
反応ノート
読み込み中…