Benzene → HCID 21162633、化合物

HRID 893991ノート

反応式

HRID 893991 の反応式
[NH2:1][CH2:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=1.[F:13][C:14]1[CH:23]=[CH:22][C:17]([CH:18]=[CH:19][CH:20]=O)=[CH:16][CH:15]=1.C1C=CC=CC=1>O>[F:13][C:14]1[CH:23]=[CH:22][C:17](/[CH:18]=[CH:19]/[CH2:20][NH:1][CH2:2][C:3]2[C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[CH:6]=[CH:5][CH:4]=2)=[CH:16][CH:15]=1

参加物

5

反応物 3

HCID 241BenzeneHCID 83551-NaphthalenemethanamineHCID 533843793-(4-Fluorophenyl)-2-propenal

生成物 1

HCID 21162633HCID 21162633、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

A mixture of 10 g of 1-aminomethylnaphthalene, 9.55 g of p-fluorocinnamaldehyde and 150 ml of benzene is heated in a reaction vessel equipped with a water separator, at reflux, until the theoretical amount of water has been separated. The mixture is cooled and evaporated to dryness. 5.78 g of the resulting Schiff's base in 60 ml of methanol, after warming to 50°, is mixed, with vigorous stirring, with 1.51 g of solid NaBH4, portionwise, and the mixture is refluxed for 20 minutes. The resulting mixture may be used as such in the next stage. The title compound can be isolated as an oil, however, by evaporation and dividing the residue between aqueous NaHCO3 solution and chloroform, drying the organic phase and evaporation.

後処理

  1. temperatureis heated in a reaction vessel
  2. customhas been separated
  3. temperatureThe mixture is cooled
  4. customevaporated to dryness
  5. temperature5.78 g of the resulting Schiff's base in 60 ml of methanol, after warming to 50°
  6. additionis mixed, with vigorous stirring, with 1.51 g of solid NaBH4
  7. temperatureportionwise, and the mixture is refluxed for 20 minutes

出典と根拠

ORDレコード
ord-e62a19f358374655bd4bc8e37ba8132b
出典データセット
uspto-grants-1981_08
特許番号
US04282251

反応ノート

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