Methylamine → N-Methyl-N-naphthylmethylamine

HRID 893992

反応式

HRID 893992 の反応式
Cl[CH2:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=1.[CH3:13][NH2:14]>C(O)C>[CH3:13][NH:14][CH2:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=1

参加物

4

反応物 2

HCID 6329MethylamineHCID 68451-Chloromethylnaphthalene

生成物 1

HCID 84474N-Methyl-N-naphthylmethylamine

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

17.6 g of 1-chloromethyl-naphthalene in 40 ml of absolute ethanol is added, dropwise, at 0° to 5°, to 100 ml of a 33% solution of methylamine in absolute ethanol. The mixture is allowed to stand overnight and is then evaporated. The residue is taken up in a little chloroform and washed with 100 ml of 1 N sodium hydroxide solution and with water. The organic phase is dried and evaporated to dryness. The residue is distilled at 0.01 Torr to obtain the heading compound as main fraction, b.p. 85°-87°.

後処理

  1. customat 0° to 5°
  2. customis then evaporated
  3. washwashed with 100 ml of 1 N sodium hydroxide solution and with water
  4. customThe organic phase is dried
  5. customevaporated to dryness
  6. distillationThe residue is distilled at 0.01 Torr
  7. customto obtain the heading compound as main fraction, b.p. 85°-87°

出典と根拠

ORDレコード
ord-be20ca3302fa4fb6bd3a91c49836586f
出典データセット
uspto-grants-1981_08
特許番号
US04282251

関連ノート

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