Ethyl 5-(4-phenylbenzoyl)pyrrole-3-carboxylate → 5-(4-Phenylbenzoyl)pyrrole-3-carboxylic Acid

HRID 894059ノート

反応式

HRID 894059 の反応式
[C:1]1([C:7]2[CH:24]=[CH:23][C:10]([C:11]([C:13]3[NH:17][CH:16]=[C:15]([C:18]([O:20]CC)=[O:19])[CH:14]=3)=[O:12])=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>CO>[C:1]1([C:7]2[CH:8]=[CH:9][C:10]([C:11]([C:13]3[NH:17][CH:16]=[C:15]([C:18]([OH:20])=[O:19])[CH:14]=3)=[O:12])=[CH:23][CH:24]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

3

反応物 1

HCID 12897070Ethyl 5-(4-phenylbenzoyl)pyrrole-3-carboxylate

生成物 1

HCID 128970715-(4-Phenylbenzoyl)pyrrole-3-carboxylic Acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Ethyl 5-(4-phenylbenzoyl)pyrrole-3-carboxylate (3.1 g.) was boiled in an open flask with 100 ml. of methanol and 70 ml. of 1 N sodium hydroxide for 1 hour by which time most of the methanol was removed by evaporation. The solution was cooled to room temperature, and product which had precipitated as the sodium salt recovered by filtration. The salt was stirred with 75 ml. of 1 N hydrochloric acid and 5-(4-phenylbenzoyl)pyrrole-3-carboxylic acid (1 g., m.p. >280° C.) recovered by filtration.

後処理

  1. customof 1 N sodium hydroxide for 1 hour by which time most of the methanol was removed by evaporation
  2. customproduct which had precipitated as the sodium salt
  3. filtrationrecovered by filtration
  4. filtrationof 1 N hydrochloric acid and 5-(4-phenylbenzoyl)pyrrole-3-carboxylic acid (1 g., m.p. >280° C.) recovered by filtration

出典と根拠

ORDレコード
ord-d2117a4c493c4680aa887f087e4b7233
出典データセット
uspto-grants-1981_08
特許番号
US04282242

反応ノート

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