Sodium Cyanide → 9-Cyanomethyl-6,11-dihydro-11-oxodibenz[b,e]oxepin
反応式
Br[CH2:2][C:3]1[CH:4]=[CH:5][C:6]2[CH2:12][O:11][C:10]3[CH:13]=[CH:14][CH:15]=[CH:16][C:9]=3[C:8](=[O:17])[C:7]=2[CH:18]=1.[C-:19]#[N:20].[Na+]>CN(C)C=O.O>[C:19]([CH2:2][C:3]1[CH:4]=[CH:5][C:6]2[CH2:12][O:11][C:10]3[CH:13]=[CH:14][CH:15]=[CH:16][C:9]=3[C:8](=[O:17])[C:7]=2[CH:18]=1)#[N:20]参加物
5
実験手順
Dissolve 6.4 gm of the bromomethyl compound of Step C in 75 cc of dimethylformamide and add 2.95 gm of sodium cyanide. Stir the mixture at room temperature for 1.5 hours. Dilute with 600 cc of water and extract three times with ether. Wash the combined organics with water, dry and strip to a solid residue. Triturate in hexane and recover the solid by filtration.
後処理
- extractionextract three times with ether
- washWash the combined organics with water
- customdry
- customTriturate in hexane
- customrecover the solid
- filtrationby filtration
出典と根拠
- ORDレコード
- ord-f2ceabd323ad4e6ab2fdf14891ece8fc
- 出典データセット
- uspto-grants-1981_08
- 特許番号
- US04282365
反応ノート
読み込み中…